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November 18.2025
3 Minutes Read

What You Must Know About Fish Oil: Medications and Supplements to Avoid Mixing

Close-up of fish oil capsules being poured from a bottle, medications not to mix with fish oil.

Understanding Fish Oil and Its Benefits

Fish oil, extracted from the tissues of oily fish, is rich in omega-3 fatty acids, which are beneficial for heart, brain, and joint health. Many adults, especially those over 60, turn to these supplements for their health-promoting properties. However, while omega-3s offer numerous health benefits, they can interact negatively with certain medications and supplements. Understanding these interactions can help consumers make safer and more informed choices.

The Risk of Mixing: Anticoagulants and Blood Thinners

One of the most critical interactions to be aware of involves anticoagulants, such as warfarin and aspirin. Fish oil has natural blood-thinning properties, and when combined with these medications, it can significantly raise the risk of bleeding. Pharmacists, like Aaron Emmel, suggest that anyone using blood thinners should consult their doctor before introducing fish oil into their regimen, as monitoring may be necessary to maintain safe blood clotting levels.

Beware of Ginkgo Biloba

Another common supplement, Ginkgo biloba, is often taken for cognitive health and reducing anxiety. However, similar to fish oil, it also has antiplatelet properties, which means it can hinder the blood's ability to clot. This combination can exacerbate risks of bruising and internal bleeding if taken together. As noted by Dr. Brynna Connor, individuals should approach this combination with caution and discuss it with a healthcare professional.

The Impact of High Doses of Vitamin E

Vitamin E is touted for its antioxidant properties and benefits to heart and eye health. However, it also plays a role in blood thinning. When consumed at higher dosages alongside fish oil, there’s an increased potential for bleeding. Most nutritional experts recommend obtaining Vitamin E through a balanced diet rich in foods like nuts and leafy greens, rather than through supplements, to avoid excessive intake.

Navigating Pain Relief: NSAIDs and Fish Oil

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, provide relief from pain and inflammation but can also heighten bleeding risks when combined with fish oil. Because both have anticoagulant effects, it’s crucial to consult a healthcare provider before using them concurrently, as stated by nutritionist Amy Goldsmith.

Blood Pressure Medications and Omega-3 Interactions

For those on blood pressure medications, the interplay with omega-3s can be complex. Fish oil can naturally lower blood pressure, and when taken with medications meant to do the same, it could lead to hypotension or excessively low blood pressure levels. Therefore, it’s vital for individuals on these medications to have open discussions with their healthcare providers regarding fish oil supplementation.

Practical Tips for Safe Fish Oil Use

Fish oil is generally safe for those who monitor its intake, particularly under the guidance of a healthcare provider. Doses exceeding 3,000 mg of combined EPA and DHA daily can lead to adverse effects and should be approached with caution. For most people, obtaining omega-3s through diet—like consuming two to three servings of fatty fish per week—is recommended. However, for individuals with specific health needs, supplements can serve as a potential therapeutic option, especially when prescribed for conditions like high triglycerides or rheumatoid arthritis.

Connecting with Health

Healthcare is an essential topic that impacts everyone. Understanding how supplements, such as fish oil, may interact with medications is crucial for personal health decisions. As consumers, staying informed about what can affect our bodies enhances our ability to make behavioral changes that promote longevity and well-being.

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